Publikationer fra forskningsgruppen for Molekylær- og Reproduktionstoksikologi

Adult female rats perinatally exposed to perfluorohexane sulfonate (PFHxS) and a mixture of endocrine disruptors display increased body/fat weights without a transcriptional footprint in fat cells

Ramskov Tetzlaff, Cecilie Nethe ; Ramhøj, Louise ; Lardenois, Aurélie ; Axelstad Petersen, Marta Zofia ; Evrard, Bertrand ; Chalmel, Frédéric ; Taxvig, Camilla ; Svingen, Terje
in: Toxicology Letters

Type: Journal article (Peer reviewed)

Status: Accepted/In press | År: 2021 | DOI: https://doi.org/10.1016/j.toxlet.2020.12.018

An advanced pluripotent stem cell test for developmental toxicity

Lauschke, Karin ; Rosenmai, Anna Kjerstine ; Treschow, Andreas Frederik ; Emnéus, Jenny ; Rasmussen, Mikkel Aabech ; Meiser, Ina ; Taxvig, Camilla ; Neubauer, Julia Christiane ; Holst, Bjørn ; Vinggaard, Anne Marie
part of: Proceedings of 11th World Congress on Alternatives and Animal Use in the Life Sciences: 3Rs in transition from development to application, pages: 224-224, 2021, The Netherlands
Presented at: 11th World Congress on Alternatives and Animal Use in the Life Sciences

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published | År: 2021

Assessment of chemical mixtures using biomarkers of combined biological activity

Rodríguez-Carrillo, Andrea ; Rosenmai, Anna Kjerstine ; Mustieles, Vicente ; Couderq, Stephan ; Fini, Jean-Baptiste ; Vela-Soria, Fernando ; Molina-Molina, Jose Manuel ; Ferrando-Marco, Patricia ; Wielsøe, Maria ; Long, Manhai ; Bonefeld-Jorgensen, Eva Cecilie ; Olea, Nicolás ; Vinggaard, Anne Marie ; Fernández, Mariana F
in: Reproductive Toxicology

Type: Journal article (Peer reviewed)

Status: Accepted/In press | År: 2021 | DOI: https://doi.org/10.1016/j.reprotox.2021.01.002

Genetic and functional insights into CDA-I prevalence and pathogenesis

Olijnik, Aude Anais ; Roy, Noémi B.A. ; Scott, Caroline ; Marsh, Joseph A. ; Brown, Jill ; Lauschke, Karin ; Ask, Katrine ; Roberts, Nigel ; Downes, Damien J. ; Brolih, Sanja ; Johnson, Errin ; Xella, Barbara ; Proven, Melanie ; Hipkiss, Ria ; Ryan, Kate ; Frisk, Per ; Mäkk, Johan ; Stattin, Eva Lena Maria ; Sadasivam, Nandini ; McIlwaine, Louisa ; Hill, Quentin A. ; Renella, Raffaele ; Hughes, Jim R. ; Gibbons, Richard J. ; Groth, Anja ; McHugh, Peter J. ; Higgs, Douglas R. ; Buckle, Veronica J. ; Babbs, Christian
in: Journal of Medical Genetics

Type: Journal article (Peer reviewed)

Status: Accepted/In press | År: 2021 | DOI: https://doi.org/10.1136/jmedgenet-2020-106880

Organophosphate ester flame retardants have antiandrogenic potential and affect other endocrine related endpoints in vitro and in silico

Rosenmai, Anna Kjerstine ; Winge, Sofia Boeg ; Möller, Morlin ; Lundqvist, Johan ; Wedebye, Eva Bay ; Nikolov, Nikolai Georgiev ; Lilith Johansson, Hanna Katarina ; Vinggaard, Anne Marie
in: Chemosphere, vol: 263

Type: Journal article (Peer reviewed)

Status: Published | År: 2021 | DOI: https://doi.org/10.1016/j.chemosphere.2020.127703

Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts

Vinggaard, Anne Marie ; Bonefeld-Jørgensen, Eva Cecilie ; Jensen, Tina Kold ; Fernandez, Mariana F ; Rosenmai, Anna Kjerstine ; Taxvig, Camilla ; Rodriguez-Carrillo, Andrea ; Wielsøe, Maria ; Long, Manhai ; Olea, Nicolas ; Antignac, Jean-Philippe ; Hamers, Timo ; Lamoree, Marja
in: Environment International, vol: 146

Type: Review (Peer reviewed)

Status: Published | År: 2021 | DOI: https://doi.org/10.1016/j.envint.2020.106191

Transcriptome analysis of fetal rat testis following intrauterine exposure to the azole fungicides triticonazole and flusilazole reveals subtle changes despite adverse endocrine effects

Draskau, Monica Kam ; Lardenois, Aurélie ; Evrard, Bertrand ; Boberg, Julie ; Chalmel, Frédéric ; Svingen, Terje
in: Chemosphere, vol: 264

Type: Journal article (Peer reviewed)

Status: Published | År: 2021 | DOI: https://doi.org/10.1016/j.chemosphere.2020.128468

A novel human pluripotent stem cell-based assay to predict developmental toxicity

Lauschke, Karin ; Rosenmai, Anna Kjerstine ; Meiser, Ina ; Neubauer, Julia Christiane ; Schmidt, Katharina ; Rasmussen, Mikkel Aabech ; Holst, Bjørn ; Taxvig, Camilla ; Emnéus, Jenny ; Vinggaard, Anne Marie
in: Archives of Toxicology, vol: 94, pages: 3831–3846

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1007/s00204-020-02856-6

Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

Ramskov Tetzlaff, Cecilie Nethe ; Svingen, Terje ; Vinggaard, Anne Marie ; Rosenmai, Anna Kjerstine ; Taxvig, Camilla
in: Environmental Toxicology, vol: 35, issue: 5, pages: 543-552

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1002/tox.22889

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Johansson, Hanna Katarina Lilith ; Svingen, Terje ; Boberg, Julie ; Fowler, Paul A ; Stead, David ; Vinggaard, Anne Marie ; Filis, Panagiotis
in: Archives of Toxicology, vol: 94, pages: 1241–1250

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1007/s00204-020-02697-3

Developmental biology meets toxicology: contributing reproductive mechanisms to build Adverse Outcome Pathways

Kam Draskau, Monica ; Spiller, Cassy M. ; Boberg, Julie ; Bowles, Josephine ; Svingen, Terje
in: Molecular Human Reproduction, vol: 26, issue: 2, pages: 111–116

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1093/molehr/gaaa001

Dietary exposure to selected chemical contaminants in fish for the Danish population

Duedahl-Olesen, Lene ; Cederberg, Tommy Licht ; Christensen, Tue ; Fagt, Sisse ; Fromberg, Arvid ; Granby, Kit ; Hansen, Max ; Boberg, Julie ; Sloth, Jens Jørgen ; Petersen, Annette
in: Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment, vol: 37, issue: 6, pages: 1027-1039

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1080/19440049.2020.1743374

Evaluating thyroid hormone disruption

Ramhøj, Louise ; Hass, Ulla ; Gilbert, Mary E. ; Wood, Carmen ; Svingen, Terje ; Usai, Diana ; Vinggaard, Anne Marie ; Mandrup, Karen ; Axelstad Petersen, Marta
in: Scientific Reports, vol: 10, issue: 1

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1038/s41598-020-59354-z

Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study

Christiansen, Sofie ; Axelstad, Marta Axelstad ; Scholze, Martin ; Johansson, Hanna Katarina Lilith ; Hass, Ulla ; Mandrup, Karen Mandrup ; Frandsen, Henrik Lauritz ; Frederiksen, Hanne ; Isling, Louise Krag ; Boberg, Julie
in: Environment International, vol: 142

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1016/j.envint.2020.105870

Hedgehog signal disruption, gonadal dysgenesis and reproductive disorders: Is there a link to endocrine disrupting chemicals?

Johansson, Hanna Katarina Lilith ; Svingen, Terje
in: Current Research in Toxicology, vol: 1, pages: 116-123

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1016/j.crtox.2020.10.001

Intrauterine exposure to diethylhexyl phthalate disrupts gap junctions in the fetal rat testis

Di Lorenzo, Mariana ; Winge, Sofia Boeg ; Svingen, Terje ; De Falco, Maria ; Boberg, Julie
in: Current Research in Toxicology, vol: 1, pages: 5-11

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1016/j.crtox.2020.02.002

Migration studies and toxicity evaluation of cyclic polyesters oligomers from food packaging adhesives

Ubeda, Sara ; Aznar, Margarita ; Rosenmai, Anna Kjerstine ; Vinggaard, Anne Marie ; Nerín, Cristina
in: Food Chemistry, vol: 311

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1016/j.foodchem.2019.125918

MIraculiX - Strengthened risk assessment of chemicals

Vinggaard, Anne Marie ; Svingen, Terje ; Boberg, Julie ; Taxvig, Camilla ; Christiansen, Sofie ; Frandsen, Henrik Lauritz ; Pedersen, Mikael ; Petersen, Annette ; Bredsdorff, Lea ; Nielsen, Elsa Ebbesen ; Jensen, Bodil Hamborg ; Dybdahl, Marianne ; Christensen, Tue ; Fagt, Sisse ; Plesning, Birgitte Møller ; Letting, Heidi Broksø ; Sztuk, Lillian ; El-Baroudy, Ulla ; Jørgensen, Vivian ; Lykkegaard Korsbech, Dorte ; Jessen, Mette Voigt ; Ørngreen, Anne-Marie ; Johansson, Hanna Katarina Lilith ; Schwartz, Camilla Victoria Lindgren ; Löbl, Nathalie Michelle ; Silva Melo, David ; Kortenkamp, Andreas ; Scholze, Martin ; Ermler, Sibylle ; Chalmel, Frederic ; Fowler, Paul ; Nørby, Erik

Type: Report

Status: Published | År: 2020

One size does not fit all in thyroid disruption: distinct thyroid hormone profiles and adverse outcomes after developmental exposure to PTU (propylthiouracil), DE-71 (brominated flame retardant) and OMC (octyl methoxycinnamate)

Axelstad Petersen, Marta Zofia ; Ramhøj, Louise ; Scholze, M. ; Köhrle, Josef ; Kortenkamp, A.
part of: 2020 SOT Annual Meeting abstract, pages: 114-114, 2020
Presented at: SOT 59th Annual Meeting

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published | År: 2020

Perinatal exposure to propylthiouracil (PTU), but not DE-71, induce heterotopia in the brain despite similar effects on serum T4 levels

Ramhøj, Louise ; Kortenkamp, A. ; Scholze, M. ; Svingen, Terje ; Köhrle, Josef ; Axelstad Petersen, Marta Zofia
part of: 2020 SOT Annual Meeting abstract, pages: 118-118, 2020
Presented at: SOT 59th Annual Meeting

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published | År: 2020

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Johansson, Hanna Katarina Lilith ; Damdimopoulou, Pauliina ; van Duursen, Majorie B.M. ; Boberg, Julie ; Franssen, Delphine ; de Cock, Marijke ; Jääger, Kersti ; Wagner, Magdalena ; Velthut-Meikas, Agne ; Xie, Yuling ; Connolly, Lisa ; Lelandais, Pauline ; Mazaud-Guittot, Severine ; Salumets, Andres ; Draskau, Monica Kam ; Filis, Panagiotis ; Fowler, Paul A. ; Christiansen, Sofie ; Parent, Anne Simone ; Svingen, Terje
in: Archives of Toxicology, vol: 94, pages: 3359–3379

Type: Review (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1007/s00204-020-02834-y

Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders

Scholze, Martin ; Taxvig, Camilla ; Kortenkamp, Andreas ; Boberg, Julie ; Christiansen, Sofie ; Svingen, Terje ; Lauschke, Karin ; Frandsen, Henrik Lauritz ; Ermler, Sibylle ; Hermann, Susan Strange ; Pedersen, Mikael ; Lykkeberg, Anne Kruse ; Axelstad Petersen, Marta Zofia ; Vinggaard, Anne Marie
in: Environmental Health Perspectives, vol: 128, issue: 11

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1289/EHP6774

Regulation of Thyroid Disrupting Chemicals to Protect the Developing Brain

Gilbert, Mary ; O'Shaughnessy, Katherine ; Axelstad Petersen, Marta
in: Endocrinology, vol: 161, issue: 10

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.1210/endocr/bqaa106

Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project

Kortenkamp, Andreas ; Axelstad Petersen, Marta ; Baig, Asma H ; Bergman, Åke ; Bornehag, Carl-Gustaf ; Cenijn, Peter ; Christiansen, Sofie ; Demeneix, Barbara ; Derakhshan, Arash ; Fini, Jean-Baptiste ; Frädrich, Caroline ; Hamers, Timo ; Hellwig, Lina ; Köhrle, Josef ; Korevaar, Tim I M ; Lindberg, Johan ; Martin, Olwenn ; Meima, Marcel E ; Mergenthaler, Philipp ; Georgiev Nikolov, Nikolai ; Du Pasquier, David ; Peeters, Robin P ; Platzack, Bjorn ; Ramhøj, Louise ; Remaud, Sylvie ; Renko, Kostja ; Scholze, Martin ; Stachelscheid, Harald ; Svingen, Terje ; Wagenaars, Fabian ; Wedebye, Eva Bay ; Zoeller, R Thomas
in: International Journal of Molecular Sciences , vol: 21, issue: 9

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.3390/ijms21093123

Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project

Duursen, Majorie B M van ; Boberg, Julie ; Christiansen, Sofie ; Connolly, Lisa ; Damdimopoulou, Pauliina ; Filis, Panagiotis ; Fowler, Paul A ; Gadella, Bart M ; Holte, Jan ; Jääger, Kersti ; Johansson, Hanna Katarina Lilith ; Li, Tianyi ; Mazaud-Guittot, Séverine ; Parent, Anne-Simone ; Salumets, Andres ; Soto, Ana M ; Svingen, Terje ; Velthut-Meikas, Agne ; Wedebye, Eva Bay ; Xie, Yuling ; Berg, Martin van den
in: International Journal of Molecular Sciences , vol: 21, issue: 9

Type: Journal article (Peer reviewed)

Status: Published | År: 2020 | DOI: https://doi.org/10.3390/ijms21093215