Our research seeks to improve on current methods for risk assessment of chemicals, both alone and in mixtures, and thereby contribute towards a healthier and more sustainable future.
With a long tradition of elucidating adverse effects caused by fetal exposure to xenobiotics, our large research team employs a broad spectrum of approaches including in vivo rat studies, an array of in vitro assays, as well as in silico modelling approaches to contribute towards new and improved risk assessment strategies.
Our research has particular focus on endocrine disruptors and their effects on reproductive, neurodevelopmental and metabolic endpoints.
Some of our specific research aims include:
- Development of tools for mixture risk assessment
- Further develop risk assessment methods by conducting studies on chemically induced reproductive toxicity and endocrine disrupting effects.
- Obtain mechanistic knowledge underpinning adverse effect outcomes (e.g. reduced thyroid hormone levels, reduced ovarian follicle reserves, shortened anogenital distance or nipple retention) and use this knowledge to devise novel in vitro and in silico methods to predict adverse outcomes of current and emerging drugs and chemicals.
- Develop novel computer- and cell-based strategies based primarily on human data to device a new matrix for predicting chemical toxicity directly relevant to human health parameters.
- Develop physiologically-based kinetic (PBK) models and validate them by in utero rat studies.