Christian Solem

Christian Solem

Lektor

DTU FØDEVAREINSTITUTTET
DTU Fødevareinstituttet

Forskningsgruppen for Mikrobiel Bioteknologi og Bioraffinering

Danmarks Tekniske Universitet

Kemitorvet

Bygning 201, rum 220

2800 Kgs. Lyngby

Hjemmeside

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Publikationer
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2020
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Complete Genome Sequence of Lactococcus lactis subsp. lactis bv. diacetylactis SD96

Dorau, Robin ; Chen, Jun ; Jensen, Peter Ruhdal ; Solem, Christian
in: Microbiology Resource Announcements, vol: 9, issue: 3

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2020     |    DOI: https://doi.org/10.1128/mra.01140-19

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Harnessing biocompatible chemistry for developing improved and novel microbial cell factories

Liu, Jian-Ming ; Solem, Christian ; Jensen, Peter Ruhdal
in: Microbial Biotechnology, vol: 13, issue: 1, pages: 54-66

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2020     |    DOI: https://doi.org/10.1111/1751-7915.13472

2019
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Development of a novel, robust and cost-efficient process for valorizing dairy waste exemplified by ethanol production

Shen, Jing ; Chen, Jun ; Jensen, Peter Ruhdal ; Solem, Christian
in: Microbial Cell Factories, vol: 18

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1186/s12934-019-1091-3

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Efficient production of α-acetolactate by whole cell catalytic transformation of fermentation-derived pyruvate

Dorau, Robin ; Chen, Lin ; Liu, Jianming ; Jensen, Peter Ruhdal ; Solem, Christian
in: Microbial Cell Factories, vol: 18, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1186/s12934-019-1271-1

 

Sweet As Sugar-Efficient Conversion of Lactose into Sweet Sugars Using a Novel Whole-Cell Catalyst

Shen, Jing ; Chen, Jun ; Jensen, Peter Ruhdal ; Solem, Christian
in: Journal of Agricultural and Food Chemistry, vol: 67, issue: 22, pages: 6257-6262

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1021/acs.jafc.9b01529

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Systems Biology – A Guide for Understanding and Developing Improved Strains of Lactic Acid Bacteria

Liu, Jianming ; Chan, Siu Hung Joshua ; Chen, Jun ; Solem, Christian ; Jensen, Peter Ruhdal
in: Frontiers in Microbiology, vol: 10

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.3389/fmicb.2019.00876

2018
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Alterations in the transcription factors GntR1 and RamA enhance the growth and central metabolism of Corynebacterium glutamicum

Wang, Zhihao ; Liu, Jianming ; Chen, Lin ; Zeng, An-Ping ; Solem, Christian ; Jensen, Peter Ruhdal
in: Metabolic Engineering, vol: 48, pages: 1-12

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.ymben.2018.05.004

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Droplet-based microfluidics as a future tool for strain improvement in lactic acid bacteria

Chen, Jun ; Vestergaard, Mike ; Shen, Jing ; Solem, Christian ; Dufva, Martin ; Jensen, Peter Ruhdal
in: FEMS Microbiology Letters, vol: 23, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1093/femsle/fny258

2017
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A bacterial cell factory for efficient production of ethanol from whey

Jensen, Peter Ruhdal ; Liu, Jianming ; Solem, Christian ; Dantoft, Shruti Harnal
Patent no.: WO2017144672, Date: 2017-08-31

Type: Patent

Status: Published     |    År: 2017

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High-level production of diacetyl in a metabolically engineered lactic acid bacterium

Solem, Christian ; Jensen, Peter Ruhdal ; Liu, Jianming
Patent no.: WO2017060455, Date: 2017-04-13

Type: Patent

Status: Published     |    År: 2017

 

A novel genetic tool for metabolic optimization of Corynebacterium glutamicum: efficient and repetitive chromosomal integration of synthetic promoter-driven expression libraries

Shen, Jing ; Chen, Jun ; Jensen, Peter Ruhdal ; Solem, Christian
in: Applied Microbiology and Biotechnology, vol: 101, issue: 11, pages: 4737-4746

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1007/s00253-017-8222-8

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Engineering Lactococcus lactis into a cell factory for production of butanol isomers

Andersen, Joakim Mark ; Mar, Mette Jurlander ; Kandasamy, Vijayalakshmi ; Liu, Jianming ; Brock-Nannestad, Theis ; Solem, Christian ; Jensen, Peter Ruhdal
part of: Book of Abstracts Sustain 2017, 2017, Technical University of Denmark, Kgs. Lyngby, Denmark
Presented at:
Sustain 2017

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    År: 2017

2016
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Micro-organism for the production of stereo-specific s, s-2,3-butanediol

Solem, Christian ; Jensen, Peter Ruhdal ; Chen, Jun ; Liu, Jianming
Patent no.: WO2016097268, Date: 2016-06-23

Type: Patent

Status: Published     |    År: 2016

 

Acetoin and 2,3 butanediol isomers synthesis in metabolically engineeredLactococcus lactis

Kandasamy, Vijayalakshmi ; Liu, Jianming ; Dantoft, Shruti Harnal ; Solem, Christian ; Jensen, Peter Ruhdal
Presented at:
Sustain-ATV Conference 2016

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2016

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A novel cell factory for efficient production of ethanol from dairy waste

Liu, Jianming ; Dantoft, Shruti Harnal ; Würtz, Anders ; Jensen, Peter Ruhdal ; Solem, Christian
in: Biotechnology for Biofuels, vol: 9, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1186/s13068-016-0448-7

 

Combining metabolic engineering and biocompatible chemistry for efficient production of food ingredients

Liu, Jianming ; Solem, Christian ; Jensen, Peter Ruhdal
Presented at:
Sustain-ATV Conference 2016

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2016

 

Combining metabolic engineering and biocompatible chemistry for high-yield production of homo-diacetyl and homo-(S,S)-2,3-butanediol

Liu, Jianming ; Chan, Siu Hung Joshua ; Brock-Nannestad, Theis ; Chen, Jun ; Lee, Sang Yup ; Solem, Christian ; Jensen, Peter Ruhdal
in: Metabolic Engineering, vol: 36, pages: 57-67

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1016/j.ymben.2016.02.008

 

Elucidation of the regulatory role of the fructose operon reveals a novel target for enhancing the NADPH supply in Corynebacterium glutamicum

Wang, Zhihao ; Chan, Siu Hung Joshua ; Sudarsan, Suresh ; Blank, Lars M. ; Jensen, Peter Ruhdal ; Solem, Christian
in: Metabolic Engineering, vol: 38, pages: 344-357

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1016/j.ymben.2016.08.004

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Integrating biocompatible chemistry and manipulating cofactor partitioning in metabolically engineeredLactococcus lactisfor fermentative production of (3S)-acetoin

Liu, Jianming ; Solem, Christian ; Jensen, Peter Ruhdal
in: Biotechnology and Bioengineering, vol: 113, issue: 12, pages: 2744-2748

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1002/bit.26038

 

Stimulation of acetoin production in metabolically engineered Lactococcus lactis by increasing ATP demand

Liu, Jianming ; Kandasamy, Vijayalakshmi ; Würtz, Anders ; Jensen, Peter Ruhdal ; Solem, Christian
in: Applied Microbiology and Biotechnology, vol: 100, issue: 2, pages: 9509-9517

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1007/s00253-016-7687-1

2015
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Adaptation of Lactococcus lactis to high growth temperature leads to a dramatic increase in acidification rate

Chen, Jun ; Shen, Jing ; Hellgren, Lars ; Jensen, Peter Ruhdal ; Solem, Christian
in: Scientific Reports, vol: 5

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1038/srep14199

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A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction

Chen, Jun ; Shen, Jing ; Solem, Christian ; Jensen, Peter Ruhdal
in: mBio (Online), vol: 6, issue: 6

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1128/mbio.01132-15

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High-level ethanol production by metabolically engineered Lactococcus lactis using economically renewable feedstocks

Liu, Jianming ; Solem, Christian ; Jensen, Peter Ruhdal
part of: Book of Abstracts. DTU's Sustain Conference 2015, 2015, Technical University of Denmark, Lyngby
Presented at:
DTU Sustain Conference 2015

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    År: 2015

 

Increased expression of pyruvate carboxylase and biotin protein ligase increases lysine production in a biotin prototrophic Corynebacterium glutamicum strain

Wang, Zhihao ; Moslehi-Jenabian, Soloomeh ; Solem, Christian ; Jensen, Peter Ruhdal
in: Engineering in Life Sciences (Online), vol: 15, issue: 1, pages: 73–82

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1002/elsc.201400185

2014
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Acetate Kinase Isozymes Confer Robustness in Acetate Metabolism

Chan, Siu Hung Joshua ; Nørregaard, Lasse ; Solem, Christian ; Jensen, Peter Ruhdal
in: PLOS ONE, vol: 9, issue: 3

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1371/journal.pone.0092256

 

Development of droplets‐based microfluidic systems for single­‐cell high‐throughput screening

Chen, Jun ; Jensen, Thomas Glasdam ; Godina, Alexei ; Solem, Christian ; Dufva, Martin ; Jensen, Peter Ruhdal
part of: Abstract Book - DTU Sustain Conference 2014, 2014, Technical University of Denmark, Kgs. Lyngby
Presented at:
DTU Sustain Conference 2014

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    År: 2014

 

Estimating biological elementary flux modes that decompose a flux distribution by the minimal branching property

Chan, Siu Hung Joshua ; Solem, Christian ; Jensen, Peter Ruhdal ; Ji, P.
in: Bioinformatics, vol: 30, issue: 22, pages: 3232-3239

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1093/bioinformatics/btu529

 

Microbial production of lysine from sustainable feedstock

Wang, Zhihao ; Grishkova, Maria ; Solem, Christian ; Jensen, Peter Ruhdal
part of: Abstract Book - DTU Sustain Conference 2014, 2014, Technical University of Denmark, Kgs. Lyngby
Presented at:
DTU Sustain Conference 2014

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    År: 2014

 

Synthetic promoter libraries for Corynebacterium glutamicum

Rytter, Jakob Vang ; Helmark, Søren ; Chen, Jun ; Lezyk, Mateusz Jakub ; Solem, Christian ; Jensen, Peter Ruhdal
in: Applied Microbiology and Biotechnology, vol: 98, issue: 6, pages: 2617-2623

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1007/s00253-013-5481-x

2013
 

Engineering strategies aimed at control of acidification rate of lactic acid bacteria

Martinussen, Jan ; Solem, Christian ; Holm, Anders Koefoed ; Jensen, Peter Ruhdal
in: Current Opinion in Biotechnology, vol: 24, issue: 2, pages: 124-129

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2013     |    DOI: https://doi.org/10.1016/j.copbio.2012.11.009

 

Oxidative Stress at High Temperatures in Lactococcus lactis Due to an Insufficient Supply of Riboflavin.

Chen, Jun ; Shen, Jing ; Solem, Christian ; Jensen, Peter Ruhdal
in: Applied and Environmental Microbiology, vol: 79, issue: 19, pages: 6140-6147

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2013     |    DOI: https://doi.org/10.1128/AEM.01953-13

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Repetitive, Marker-Free, Site-Specific Integration as a Novel Tool for Multiple Chromosomal Integration of DNA

Petersen, Kia Vest ; Martinussen, Jan ; Jensen, Peter Ruhdal ; Solem, Christian
in: Applied and Environmental Microbiology, vol: 79, issue: 12, pages: 3563-3569

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2013     |    DOI: https://doi.org/10.1128/AEM.00346-13

 

Rewiring Lactococcus lactis for Ethanol Production

Solem, Christian ; Dehli, Tore Ibsen ; Jensen, Peter Ruhdal
in: Applied and Environmental Microbiology, vol: 79, issue: 8, pages: 2512-2518

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2013     |    DOI: https://doi.org/10.1128/AEM.03623-12

2012
 

Tunable promoters in synthetic and systems biology.

Dehli, Tore ; Solem, Christian ; Jensen, Peter Ruhdal
in: Sub-cellular biochemistry., vol: 64, pages: 181-201

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012

2011
 

Towards a quantitative prediction of the fluxome from the proteome

Rossell, Sergio ; Solem, Christian ; Jensen, Peter Ruhdal ; Heijnen, Joseph J.
in: Metabolic Engineering, vol: 13, issue: 3, pages: 253-262

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2011     |    DOI: https://doi.org/10.1016/j.ymben.2011.01.010

2010
 

Metabolic and Transcriptional Response to Cofactor Perturbations in Escherichia coli

Holm, Anders Koefoed ; Blank, L.M. ; Oldiges, M. ; Schmid, A. ; Solem, Christian ; Jensen, Peter Ruhdal ; Vemuri, G.N.
in: Journal of Biological Chemistry, vol: 285, issue: 23, pages: 17498-17506

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1074/jbc.M109.095570

 

Phosphoglycerate Mutase Is a Highly Efficient Enzyme without Flux Control in Lactococcus lactis

Solem, Christian ; Petranovic, D. ; Købmann, Brian ; Mijakovic, Ivan ; Jensen, Peter Ruhdal
in: Journal of Molecular Microbiology and Biotechnology, vol: 18, issue: 3, pages: 174-180

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1159/000315458

2008
 

Co-factor engineering in lactobacilli: Effects of uncoupled ATPase activity on metabolic fluxes in Lactobacillus (L.) plantarum and L. sakei

Rud, Ida ; Solem, Christian ; Jensen, Peter Ruhdal ; Axelsson, Lars ; Naterstad, Kristine
in: Metabolic Engineering, vol: 10, issue: 5, pages: 207-215

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2008     |    DOI: https://doi.org/10.1016/j.ymben.2008.06.001

 

Control analysis of the role of triosephosphate isomerase in glucose metabolism in Lactococcus lactis

Solem, Christian ; Købmann, Brian Jensen ; Jensen, Peter Ruhdal
in: I E T Systems Biology, vol: 2, issue: 2, pages: 64-72

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2008     |    DOI: https://doi.org/10.1049/iet-syb:20070002

 

Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions

Købmann, Brian Jensen ; Blank, Lars Mathias ; Solem, Christian ; Petranovic, Dina ; Nielsen, Lars K. ; Jensen, Peter Ruhdal
in: Biotechnology and Applied Biochemistry, vol: 50, pages: 25-33

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2008     |    DOI: https://doi.org/10.1042/BA20070132

 
 

The extent of co-metabolism of glucose and galactose by L. lactis changes with the expression of the lacSZ operon from Streptococcus thermophilus

Solem, Christian ; Købmann, Brian Jensen ; Jensen, Peter Ruhdal
in: Biotechnology and Applied Biochemistry, vol: 50, issue: 1, pages: 35-40

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2008     |    DOI: https://doi.org/10.1042/BA20070157

2007
 

The las enzymes control pyruvate metabolism in Lactococcus lactis during growth on maltose

Solem, Christian ; Købmann, Brian Jensen ; Yang, F ; Jensen, Peter Ruhdal
in: Journal of Bacteriology, vol: 189, issue: 18, pages: 6727-30

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2007     |    DOI: https://doi.org/10.1128/JB.00902-07

2006
 

Control analysis of the importance of phosphoglycerate enolase for metabolic fluxes in Lactococcus lactis subsp. lactis IL1403.

Købmann, Brian Jensen ; Solem, Christian ; Jensen, Peter Ruhdal
in: IEE Proceedings - Systems Biology, vol: 153, issue: 5, pages: 346-349

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2006

 

Lactococcus lactis - traditional and GMO strains

Jensen, Peter Ruhdal ; Købmann, Brian Jensen ; Solem, Christian
in: Toxicology Letters, vol: 164, pages: S317-S317

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    År: 2006

2005
 

Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis

Købmann, Brian Jensen ; Solem, Christian ; Jensen, Peter Ruhdal
in: Journal of Biotechnology, vol: 118, issue: Supplement 1, pages: S162-S162
Presented at:
12th European Congress on Biotechnology

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    År: 2005

 

Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis

Købmann, Brian Jensen ; Solem, Christian ; Jensen, Peter Ruhdal
in: FEBS Journal, vol: 272, issue: 9, pages: 2292-2303

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2005     |    DOI: https://doi.org/10.1111/j.1742-4658.2005.04656.x

 

Triosephosphate isomerase has no control on the glycolytic flux and metabolic shift in Lactococcus lactis IL1403

Solem, Christian ; Købmann, Brian Jensen ; Jensen, Peter Ruhdal
in: Journal of Biotechnology, vol: 118, pages: S158-S158

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    År: 2005

2004
 

Hvad kontrollorer syrningseffektiviteten af den primære starter?

Købmann, Brian Jensen ; Solem, Christian ; Jensen, Peter Ruhdal
in: Mælkeritidende, vol: 3, pages: 55-64

Type: Journal article

Status: Published     |    År: 2004

 

Kontrolanalyse af glykosen i mikrobielle systemer

Købmann, Brian Jensen ; Solem, Christian ; Jensen, Peter Ruhdal
in: Dansk Kemi, vol: 85, pages: 22-26

Type: Journal article

Status: Published     |    År: 2004

2003
 

Glyceraldehyde-3-phosphate dehydrogenase has no control over glycolytic flux in Lactococcus lactis MG1363

Solem, Christian ; Købmann, Brian Jensen ; Jensen, Peter Ruhdal
in: Journal of Bacteriology, vol: 185, issue: 5, pages: 1564-1571

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2003

2002
 

Experimental determination of control of glycolysis in Lactococcus lactis

Købmann, Brian Jensen ; Andersen, Heidi Winterberg ; Solem, Christian ; Jensen, Peter Ruhdal
in: Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, vol: 82, issue: 1-4, pages: 237-248

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2002

 

Expression of genes encoding F-1-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis

Købmann, Brian Jensen ; Solem, Christian ; Pedersen, M.B. ; Nilsson, D. ; Jensen, Peter Ruhdal
in: Applied and Environmental Microbiology, vol: 68, issue: 9, pages: 4274-4282

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2002

 

Modulation of gene expression made easy

Solem, Christian ; Jensen, Peter Ruhdal
in: APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol: 68, issue: 5, pages: 2397-2403

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2002

 

The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth.

Købmann, Brian Jensen ; Westerhoff, H.V. ; Snoep, J.L. ; Solem, Christian ; Pedersen, Martin Bastian ; Nilsson, D. ; Michelsen, Ole ; Jensen, Peter Ruhdal
in: Molecular Biology Reports, vol: 29, issue: 1-2, pages: 41-45

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2002

 

Totalt regulerbare promotorer i skræddersyede starterkulturer

Johansen, Annette Helle ; Andersen, Heidi Winterberg ; Solem, Christian ; Jensen, Peter Ruhdal
in: Mælkeritidende, issue: 11, pages: 274-277

Type: Journal article

Status: Published     |    År: 2002

2001
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Twofold reduction of phosphofructokinase activity in Lactococcus lactis results in strong decreases in growth rate and in glycolytic flux

Andersen, Heidi Winterberg ; Solem, Christian ; Hammer, Karin ; Jensen, Peter Ruhdal
in: Journal of Bacteriology, vol: 183, issue: 11, pages: 3458-3467

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2001     |    DOI: https://doi.org/10.1128/JB.183.11.3458-3467.2001


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4 APRIL 2020