Photo: National Food Institute, Technical University of Denmark

Decrease in antimicrobial use in animals in Denmark

Thursday 08 Oct 15

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Flemming Bager
Head of Division
National Food Institute
+45 35 88 69 96

Antimicrobial use in animals has decreased in 2014 due mainly to decreased consumption in the pig production. In general very little of the critically important antimicrobials – which are used to treat humans – is used in the production of livestock. The use of critically important antimicrobials in companion animals has also decreased. These are some of the findings in the annual DANMAP report from Statens Serum Institut and the National Food Institute, Technical University of Denmark. DANMAP is the Danish integrated antimicrobial resistance monitoring and research programme.

In 2014, the total use of antimicrobials in livestock and pets in Denmark was 2% lower than the previous year when measured in kilograms. This decrease is mainly attributed to a 5% decrease in the consumption of antimicrobials in pig production, which accounts for about 86% of meat production in Denmark. However, antimicrobial usage in poultry and cattle has continued to increase in 2014.

Distributed by species, pigs account for around 76% of antimicrobial use in 2014, cattle 11%, aquaculture 4%, poultry 1%, fur animals 4%, and pets, horses and other companion animals the remaining 4%.

Decreased use in pigs

Antimicrobial consumption in pigs measured in doses has decreased in all three age groups: sows/piglets (5%), weaners (2%) and finishers (7%). This is primarily due to a decreased use of tetracyclines, and to a lesser degree pleuromutilins and macrolides. Thus, the consumption in pig production is 12% lower than in 2009, when the highest consumption was recorded since Danish farmers stopped using antimicrobial growth promoters. While there has been a decrease in antimicrobial use there has been in an increase in the number of pigs produced in 2014 compared to the year before.

"It is very positive that antimicrobial use in pigs has dropped considerably over the past year, as this is a necessity if we are to tackle the problem of antimicrobial resistant bacteria."

"It is very positive that antimicrobial use in pigs has dropped considerably over the past year, as this is a necessity if we are to tackle the problem of antimicrobial resistant bacteria," Head of Division Flemming Bager from the National Food Institute says.

In 2014 Danish pig producers made a voluntary commitment to halving consumption of tetracyclines by the end of 2015.

DANMAP 2014 shows for the first time how the use of vaccines and zinc oxide in pigs has developed over the past ten years. Vaccinations can help reduce the need to treat animals with antimicrobials, while zinc oxide is used to prevent diarrhea in piglets.

Increased use in poultry

However, in 2014 there has been a 22% increase in the consumption of antimicrobials in poultry production compared to the previous year, making it the highest consumption in ten years. Particularly the use of tetracyclines and broad-spectrum penicillins has increased over the past year.

"Antimicrobial consumption in poultry constitutes less than 2% of the total consumption and a few disease outbreaks can cause significant fluctuations in annual consumption. The increase we have seen over the last two years can be explained by an overall higher incidence of both diarrhea and joint problems in broiler production and an increased incidence of respiratory disease in turkeys," Flemming Bager explains.

Consumption of critically important antimicrobials still low

Consumption of critically important antimicrobials – such as fluoroquinolones and cephalosporins – in animal production is still low.

For a third consecutive year the use of fluoroquinolones in pigs was very low and constitutes less than 1 per mille of the total consumption in pigs.

In 2010 Danish pork producers introduced a voluntary ban on the use of cephalosporins where other effective treatment options are available. In August 2014, the Danish Agriculture & Food Council encouraged cattle farmers to also only use cephalosporins where this is the only effective treatment option. Cephalosporins are not used in poultry production.

Increased use in cattle, horses and fish

Overall, consumption of antimicrobials in the treatment of cattle, horses and fish has increased in 2014 compared to the year before. However, this is not due to an increase in the use of critically important antimicrobials, as consumption of cephalosporins and fluoroquinolones in 2014 is lower than what was recorded in 2013. At the same time especially the use of penicillins and sulfonamide/trimethroprim products has increased.

Companion animals account for nearly 47% of the combined veterinary consumption of fluoroquinolones and approximately 66% of the total use of cephalosporins in animals.

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Since 1995 the DANMAP programme has monitored the use of antimicrobials in humans and animals in Denmark, and the occurrence of antimicrobial resistance in bacteria in animals, people and foods. The organisations behind DANMAP are the National Food Institute, the National Veterinary Institute (both institutes are under the Technical University of Denmark) and Statens Serum Institute. The DANMAP report is prepared by the National Food Institute and Statens Serum Institute.

Find the DANMAP-rapporten on DANMAP’s website.

FACTS ABOUT ANTIMICROBIAL RESISTANCE

Treatment with antimicrobials is intended to kill pathogenic bacteria. Unfortunately, antimicrobials also cause the bacteria to protect themselves by developing resistance to the type of antimicrobials that are used to treat them which causes the antimicrobials to lose their effectiveness. Resistant bacteria can be transmitted between humans, and bacteria can infect each other with resistance. However, resistant bacteria are poor at surviving if antimicrobials are not present. Therefore, it is important to have an overall focus on using as few antimicrobials as possible for the treatment of both animals and humans.

Bacteria know no borders, therefore antimicrobial resistance in one country can cause problems outside of its borders. As such the use of antimicrobials in both animals and humans is a global problem.

Not all antimicrobials are the same. Some are narrow spectrum and affect only individual groups of bacteria. They are used when you know which bacteria are causing the disease. Others are broad spectrum and affect numerous groups of bacteria at the same time. They can therefore be used to treat a disease before knowing which bacteria is the cause. However, they often also kill useful and harmless bacteria such as bacteria from the intestine, which may lead to the emergence of resistant bacteria.

Not all antimicrobials are equally important in the treatment of humans. WHO has declared a number of antimicrobials to be ’critically important’, because they are the only or one of only a few antimicrobials, which can be used to treat serious or life-threatening infections in humans. These types include carbapenems, third and fourth generation cephalosporins, fluoroquinolones and macrolides.

http://www.food.dtu.dk/english/news/2015/10/decrease-in-antimicrobial-use-in-animals-in-denmark?id=e3cb221a-75c0-48d8-8ec8-dbb6dfc49023
22 JANUARY 2019